Alternative salt bridge formation in Aβ—a hallmark of early-onset Alzheimer's disease?
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چکیده
منابع مشابه
Alternative salt bridge formation in Aβ—a hallmark of early-onset Alzheimer's disease?
Recently the 3D structure of the Osaka mutant form (E22Δ) of Amyloid-β1-40 has been determined. We here compare the NMR chemical-shift with the published shifts of a brain-seeded form of wild-type Aβ and suggest that the determined mutant fold is accessible to the wild-type protein as well, with small conformational adaptations which accommodate the E22 residue missing in the Osaka mutant. In a...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Biosciences
سال: 2015
ISSN: 2296-889X
DOI: 10.3389/fmolb.2015.00014